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Systems biomedical analysis of Schistosoma japonicum

Ze-Guang HAN MD,

《医学前沿（英文）》 2010年第4卷第2期页码 157-165 doi: 10.1007/s11684-010-0034-5

摘要： Human schistosomiasis, caused mainly by three principal species including , , and , remains a major public health concern worldwide. is prevalent in southern China, being a major disease risk for 66 million people. The blood fluke has a complex life cycle for survival: as a free-living form in fresh water and as a parasite in the snail intermediate and vertebrate definitive hosts. Systems-based biomedical analyses, including genomic, transcriptomic, proteomic and metabonomic approaches, have been performed on the schistosome. These comprehensive investigations have not only characterized the genomic features but also chartered gene and protein expression profiles across genders and developmental stages. The integration of the huge information will lay a global and solid foundation for the molecular architecture of the biology, pathogenesis, and host-parasite interactions of the human blood fluke, which will facilitate the development of a new antischistosomal vaccine and drugs as well as diagnostic markers for the treatment and control of schistosomiasis.

关键词： Schistosoma japonicum systems biomedical analysis

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Personalized biomedical devices & systems for healthcare applications

I-Ming CHEN, Soo Jay PHEE, Zhiqiang LUO, Chee Kian LIM

《机械工程前沿（英文）》 2011年第6卷第1期页码 3-12 doi: 10.1007/s11465-011-0209-z

摘要：

With the advancement in micro- and nanotechnology, electromechanical components and systems are getting smaller and smaller and gradually can be applied to the human as portable, mobile and even wearable devices. Healthcare industry have started to benefit from this technology trend by providing more and more miniature biomedical devices for personalized medical treatments in order to obtain better and more accurate outcome. This article introduces some recent development in non-intrusive and intrusive biomedical devices resulted from the advancement of niche miniature sensors and actuators, namely, wearable biomedical sensors, wearable haptic devices, and ingestible medical capsules. The development of these devices requires carful integration of knowledge and people from many different disciplines like medicine, electronics, mechanics, and design. Furthermore, designing affordable devices and systems to benefit all mankind is a great challenge ahead. The multi-disciplinary nature of the R&D effort in this area provides a new perspective for the future mechanical engineers.

关键词： personalized medical devices wearable sensor haptic device ingestible medical capsule

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Fluorescent probes and functional materials for biomedical applications

《化学科学与工程前沿（英文）》 2022年第16卷第10期页码 1425-1437 doi: 10.1007/s11705-022-2163-1

摘要： Due to their simplicity in preparation, sensitivity and selectivity, fluorescent probes have become the analytical tool of choice in a wide range of research and industrial fields, facilitating the rapid detection of chemical substances of interest as well as the study of important physiological and pathological processes at the cellular level. In addition, many long-wavelength fluorescent probes developed have also proven applicable for in vivo biomedical applications including fluorescence-guided disease diagnosis and theranostics (e.g., fluorogenic prodrugs). Impressive progresses have been made in the development of sensing agents and materials for the detection of ions, organic small molecules, and biomacromolecules including enzymes, DNAs/RNAs, lipids, and carbohydrates that play crucial roles in biological and disease-relevant events. Here, we highlight examples of fluorescent probes and functional materials for biological applications selected from the special issues “Fluorescent Probes” and “Molecular Sensors and Logic Gates” recently published in this journal, offering insights into the future development of powerful fluorescence-based chemical tools for basic biological studies and clinical translation.

关键词： fluorescent probes imaging cell biomedicine biomolecules

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Biomedical sensor technologies on the platform of mobile phones

Lin LIU, Jing LIU

《机械工程前沿（英文）》 2011年第6卷第2期页码 160-175 doi: 10.1007/s11465-011-0216-0

摘要：

Biomedical sensors have been widely used in various areas of biomedical practices, which play an important role in disease detection, diagnosis, monitoring, treatment, health management, and so on. However, most of them and their related platforms are generally not easily accessible or just too expensive or complicated to be kept at home. As an alternative, new technologies enabled from the mobile phones are gradually changing such situations. As can be freely available to almost everyone, mobile phone offers a unique way to improve the conventional medical care through combining with various biomedical sensors. Moreover, the established systems will be both convenient and low cost. In this paper, we present an overview on the state-of-art biomedical sensors, giving a brief introduction of the fundamental principles and showing several new examples or concepts in the area. The focus was particularly put on interpreting the technical strategies to innovate the biomedical sensor technologies based on the platform of mobile phones. Some challenging issues, including feasibility, usability, security, and effectiveness, were discussed. With the help of electrical and mechanical technologies, it is expected that a full combination between the biomedical sensors and mobile phones will bring a bright future for the coming pervasive medical care.

关键词： biomedical sensor pervasive technology mobile phone combined system health management

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A mini review: Shape memory polymers for biomedical applications

Kaojin Wang, Satu Strandman, X. X. Zhu

《化学科学与工程前沿（英文）》 2017年第11卷第2期页码 143-153 doi: 10.1007/s11705-017-1632-4

摘要： Shape memory polymers (SMPs) are smart materials that can change their shape in a pre-defined manner under a stimulus. The shape memory functionality has gained considerable interest for biomedical applications, which require materials that are biocompatible and sometimes biodegradable. There is a need for SMPs that are prepared from renewable sources to be used as substitutes for conventional SMPs. In this paper, advances in SMPs based on synthetic monomers and bio-compounds are discussed. Materials designed for biomedical applications are highlighted.

关键词： shape memory polymer biodegradability biocompatibility biomedical application bile acids

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Introduction to the Special Section on Biomedical Devices for Personal Health Applications

I-Ming CHEN

《机械工程前沿（英文）》 2011年第6卷第1期页码 1-2 doi: 10.1007/s11465-011-0210-6

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Multiscale process systems engineering—analysis and design of chemical and energy systems from molecular

《化学科学与工程前沿（英文）》 2022年第16卷第2期页码 137-140 doi: 10.1007/s11705-021-2135-x

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Functional ferritin nanoparticles for biomedical applications

Zhantong Wang, Haiyan Gao, Yang Zhang, Gang Liu, Gang Niu, Xiaoyuan Chen

《化学科学与工程前沿（英文）》 2017年第11卷第4期页码 633-646 doi: 10.1007/s11705-017-1620-8

摘要： Ferritin, a major iron storage protein with a hollow interior cavity, has been reported recently to play many important roles in biomedical and bioengineering applications. Owing to the unique architecture and surface properties, ferritin nanoparticles offer favorable characteristics and can be either genetically or chemically modified to impart functionalities to their surfaces, and therapeutics or probes can be encapsulated in their interiors by controlled and reversible assembly/disassembly. There has been an outburst of interest regarding the employment of functional ferritin nanoparticles in nanomedicine. This review will highlight the recent advances in ferritin nanoparticles for drug delivery, bioassay, and molecular imaging with a particular focus on their biomedical applications.

关键词： nanomedicine ferritin drug delivery bioassay molecular imaging

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Concrete corrosion in wastewater systems: Prediction and sensitivity analysis using advanced extreme

Mohammad ZOUNEMAT-KERMANI, Meysam ALIZAMIR, Zaher Mundher YASEEN, Reinhard HINKELMANN

《结构与土木工程前沿（英文）》 2021年第15卷第2期页码 444-460 doi: 10.1007/s11709-021-0697-9

摘要： The implementation of novel machine learning models can contribute remarkably to simulating the degradation of concrete due to environmental factors. This study considers the sulfuric acid corrosive factor in wastewater systems to simulate concrete mass loss using five machine learning models. The models include three different types of extreme learning machines, including the standard, online sequential, and kernel extreme learning machines, in addition to the artificial neural network, classification and regression tree model, and statistical multiple linear regression model. The reported values of concrete mass loss for six different types of concrete are the target values of the machine learning models. The input variability was assessed based on two scenarios prior to the application of the predictive models. For the first assessment, the machine learning models were developed using all the available cement and concrete mixture input variables; the second assessment was conducted based on the gamma test approach, which is a sensitivity analysis technique. Subsequently, the sensitivity analysis of the most effective parameters for concrete corrosion was tested using three different approaches. The adopted methodology attained optimistic and reliable modeling results. The online sequential extreme learning machine model demonstrated superior performance over the other investigated models in predicting the concrete mass loss of different types of concrete.

关键词： sewer systems environmental engineering data-driven methods sensitivity analysis

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Sustainability performance analysis of environment innovation systems using a two-stage network DEA model

《工程管理前沿（英文）》页码 425-438 doi: 10.1007/s42524-022-0205-5

摘要： The term environmental innovation system refers to an innovation network composed of enterprises, universities, and research institutions involved in the development and diffusion of environmental technology, with the participation of a government. An environmental innovation system not only exerts important impact on the achievement of carbon neutrality but also affects social and economic activities. Investigations on environmental innovation system performance constantly assume a single-stage independent system while ignoring its internal structure. However, such systems are composed of environmental innovation research and development (R&D) and environmental innovation conversion subsystems. A two-stage data envelopment analysis (DEA) model is developed in this study to analyze the efficiency of Chinese regional environmental innovation system by opening the “black box” and considering shared resources. Empirical results indicated that China presents high overall environmental innovation efficiency although some regions need to improve. Regions with low efficiencies in both environmental innovation R&D (EIR) and environmental innovation conversion (EIC) subsystems should expand their investment in and strengthen the management of environmental innovation resources. Regions with low EIR efficiency should improve the absorption and transformation of environmental innovation achievements. Regions with low EIC efficiency should increase investment in the commercialization of environmental innovation achievements and encourage green economy industries, such as new energy, art, tourism, and environmental protection.

关键词： data envelopment analysis environmental efficiency environmental innovation system shared resources two-stage structure

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New analysis model for rotor-bearing systems based on plate theory

Zhinan ZHANG, Mingdong ZHOU, Weimin DING, Huifang MA

《机械工程前沿（英文）》 2019年第14卷第4期页码 461-473 doi: 10.1007/s11465-019-0525-2

摘要： The purpose of this work is to develop a new analysis model for angular-contact, ball-bearing systems on the basis of plate theory instead of commonly known approaches that utilize spring elements. Axial and radial stiffness on an annular plate are developed based on plate, Timoshenko beam, and plasticity theories. The model is developed using theoretical and inductive methods and validated through a numerical simulation with the finite element method. The new analysis model is suitable for static and modal analyses of rotor-bearing systems. Numerical examples are presented to reveal the effectiveness and applicability of the proposed approach.

关键词： rotor-bearing system rolling element bearing plate theory finite element analysis

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Effects of design parameters on performance and cost analysis of combined ultraviolet-biofilter systems

Can WANG, Jinying XI, Hongying HU, Insun KANG

《环境科学与工程前沿（英文）》 2012年第6卷第4期页码 588-594 doi: 10.1007/s11783-012-0433-8

摘要： A conceptual mathematical model was used to evaluate the design parameters of a combined ultraviolet (UV)-biofilter system, and perform a cost analysis. Results showed that the UV light source strength and the gas residence times in the UV system (UVRT) and biofilter (EBRT) had positive effects on the overall chlorobenzene removal efficiency of the system. High ratio of UVRT to EBRT improved the removal efficiency, suggesting that the UV system has a greater effect on the overall performance of the system compared with the biofilter. Analysis of the capital and operating costs showed that the capital costs of the standalone biofilter system were much higher than those of the standalone UV system. However, the biofilter operating costs were lower than those of the UV system. The operating costs of the combined UV-biofilter system increased with increasing UVRT/EBRT ratio, whereas its capital costs decreased.

关键词： volatile organic compounds ultraviolet (UV) photodegradation biofilter modeling cost analysis

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CLIMATE-CHANGE-INDUCED TEMPORAL VARIATION IN PRECIPITATION INCREASES NITROGEN LOSSES FROM INTENSIVE CROPPING SYSTEMS: ANALYSIS WITH A TOY MODEL

《农业科学与工程前沿（英文）》 2022年第9卷第3期页码 457-464 doi: 10.15302/J-FASE-2022452

摘要：

● A simple model was used to evaluate how increasing temporal variability in precipitation influences crop yields and nitrogen losses.

关键词： crop yield fertilizer timing nitrogen loss precipitation variability toy model

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Life cycle cost savings analysis on traditional drainage systems from low impact development strategies

Pengfei ZHANG, Samuel T. ARIARATNAM

《工程管理前沿（英文）》 2021年第8卷第1期页码 88-97 doi: 10.1007/s42524-020-0063-y

摘要： Areas that are covered with natural vegetation have been converted into asphalt, concrete, or roofed structures and have increased surface impermeability and decreased natural drainage capability. Conventional drainage systems were built to mimic natural drainage patterns to prevent the occurrence of waterlogging in developed sites. These drainage systems consist of two major components: 1) a stormwater conduit system, and 2) a runoff storage system. Runoff storage systems contain retention basins and drywells that are used to store and percolate runoff, whereas conduit systems are combination of catch basins and conduit pipes used to collect and transport runoff. The construction of these drainage systems is costly and may cause significant environmental disturbance. In this study, low impact development (LID) methods that consist of extensive green roofs (GRs) and permeable interlocking concrete pavements (PICPs) are applied in real-world construction projects. Construction project documents were reviewed, and related cost information was gathered through the accepted bidding proposals and interviews of specialty contractors in the metropolitan area of Phoenix, Arizona. Results indicate that the application of both LID methods to existing projects can save an average of 27.2% in life cycle costs (LCC) for a 50-year service life and 18.7% in LCC for a 25-year service life on the proposed drainage system, respectively.

关键词： low impact development traditional drainage system hydraulic benefits life-cycle cost